Residual solvents are organic volatile chemicals that are used or produced in the manufacture of drug substances or excipients, or in the preparation of drug products, and are not removed in process. As these solvents have no therapeutic benefits, and could cause unwanted toxicities, they should not be present or present in the least amount possible.

As per TGA Quality guidelines, residual solvents in medicinal cannabis products should be under the acceptable limits stated in the ICH guideline Q3C (R6) on impurities: guideline for residual solvents.

Ash is the inorganic residue remaining after the water and organic matter have been removed by heating in the presence of oxidizing agents. Ash is the measures of the total amount of minerals in a sample. The TGO 93 Standard for Medicinal Cannabis has set a limit of 20.0% for the total ash content of a medicinal cannabis product. 

Residual solvent screen

An analytical screen quantifying the levels of residual solvents across all classes including aromatic, aliphatic, alcohols and chlorinated solvents.

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ASh screen

An analytical screen quantifying the levels of ash in a sample.

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